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For U.S. Residents Only

Glossary

Anemia
Lower than normal red blood cell count; a possible side effect of chemotherapy.

Antiemetics
A medication that helps decrease or prevent nausea and vomiting.

Cancer
Diseases characterized by abnormal and uncontrolled cell division. Cancer cells can attack tissues in the body and possibly spread to other parts of the body. There are many different kinds of cancer.

Carcinoma in situ
Describes a condition in the earliest stage; also known as precancerous, or stage 0.

Chemotherapy
Type of cancer treatment using drugs to destroy cancer cells.

Colon Cancer
Cancer of the colon tissues.

Colonoscopy
A procedure to screen for cancer; a flexible tube is placed through the rectum into the colon so the doctor can see the entire colon.

Colorectal Cancer
Cancer of the colon and/or rectum.

Colostomy
An opening in the abdomen used to rid the body of waste; sometimes needed after surgery for cancer of the rectum (usually temporarily).

Dehydrated
Condition that occurs when the body loses too much water. Dehydration can be caused by severe diarrhea or vomiting.

Disease-Free Survival
The time following treatment in which no cancer is detected in the body.

Dysesthesia
Condition that distorts the senses — usually touch. Normal stimuli, such as a light touch, may feel unpleasant or painful to someone with dysesthesia.

Fecal Occult Blood Test
A test used to screen for colorectal cancer; a stool sample is examined for blood.

Flexible Sigmoidoscopy
A test to screen for cancer; a lighted tube is placed in the rectum so the doctor can look inside.

Leukopenia
Lower than normal white blood cell count; a possible side effect of chemotherapy.

Lymph Nodes
A small group of lymphatic tissue surrounded by connective tissue. Lymph nodes filter lymphatic fluid (clear fluid carrying the cells that help fight diseases and infections) and store lymphocytes (types of white blood cells).

Metastasis
A process that takes place in advanced cancer; cancer spreads from the primary site to other parts of the body.

Metastatic
When cancer has spread from one body part to another.

Neuropathy
Nerve condition that affects peripheral nerve function (parts of the nervous system besides the brain and spinal cord). Neuropathy causes pain, tingling, numbness, swelling and muscle weakness. Injury, infection, toxic substances, drugs (such as anticancer drugs), or diseases (such as cancer, diabetes, kidney failure or malnutrition) can cause neuropathy.

Polyp
A small growth of tissue on the lining of the colon or rectum that can sometimes become cancerous.

Staging
A way to describe how advanced a cancer is; helps the doctor forecast how well a cancer patient may do over time and how to best treat the patient.

Thrombocytopenia
A lower than normal platelet count that results in increased risk of bleeding; a possible side effect of chemotherapy.

Title

ELOXATIN, used in combination with infusional 5-FU/LV, is indicated for

Clinical Safety Considerations

ELOXATIN should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate diagnostic and treatment facilities are readily available.

Anaphylactic-like reactions to ELOXATIN have been reported and may occur within minutes of ELOXATIN administration. Epinephrine, corticosteroids, and antihistamines have been employed to alleviate symptoms, and discontinuation of ELOXATIN therapy may be required.

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