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ELOXATIN (oxaliplatin injection) Dosing Regimen

ELOXATIN (oxaliplatin injection), in combination with 5-fluorouracil and leucovorin, is generally given every two weeks. This is called a cycle of treatment. In adjuvant therapy (after surgery), a total of 12 cycles over a 6-month period of time is usually recommended. For advanced colorectal cancer, treatment is usually recommended until disease progression or unacceptable toxicity. Speak to your doctor about determining what your course of treatment should be.

Before you receive each cycle of ELOXATIN (oxaliplatin injection), your doctor will perform some blood tests. These tests are necessary because ELOXATIN (oxaliplatin injection) can affect your bone marrow, where blood cells are made. The tests include counts of your red blood cells, white blood cells, and platelets. Depending on the results of these tests and the side effects you may experience with ELOXATIN (oxaliplatin injection), your doctor may decide to delay, discontinue, or lower your dosing regimen. If you have trouble coping with the side effects of treatment, talk to your doctor. Always let your nurse and doctor know before your next treatment how you did since your last visit.

Important Safety Information

Anaphylactic-like reactions to ELOXATIN have been reported and may occur within minutes of ELOXATIN administration. Epinephrine, corticosteroids, and antihistamines have been employed to alleviate symptoms.

  • Do not take ELOXATIN if you are allergic to any of the ingredients in ELOXATIN or other medicines that contain platinum. Tell your doctor right away if you feel like your throat is closing up, have shortness of breath, a flushed face, a rash, itching/hives, swelling of lips or tongue, sudden cough, dizziness, sweating or chest pain.
  • ELOXATIN can cause nerve problems. Tell your doctor right away if you become sensitive to cold temperatures and cold objects; have trouble breathing, swallowing or saying words; experience jaw tightness, odd feelings in your tongue, or chest pressure; pain; tingling or burning in your hands, feet or around your mouth or throat.
  • Tell your doctor if you develop a dry cough or have trouble breathing; these may be signs of serious lung disease.
  • ELOXATIN can cause liver problems (hepatotoxicity); your doctor will do blood tests to watch for this.
  • Because of the potential risk of fetal harm, pregnant women should not receive ELOXATIN. Women of childbearing potential should avoid becoming pregnant while receiving ELOXATIN.
  • ELOXATIN can cause a decrease in white blood cells, which can lead to infections. Tell your doctor right away if develop any of the following signs of infection: fever, chills, or shivering; cough that brings up mucus, burning or pain on urination, pain on swallowing; sore throat; or redness or swelling at injection site.
  • Other common side effects of ELOXATIN include a decrease in white blood cells, red blood cells, and platelets, nausea, vomiting, diarrhea, and tiredness.
  • Tell your doctor about all the medications you take, including prescription and non-prescription medications, vitamins and herbal supplements.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of ELOXATIN. For more information, ask your doctor or pharmacist.

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